Overexpression of Cytochrome P450 Epoxygenases Prevents Development of Hypertension in Spontaneously Hypertensive Rats by Enhancing Atrial Natriuretic Peptide

Cytochrome P450 (P450)-derived epoxyeicosatrienoic acids (EETs) exert well recognized vasodilatory, diuretic, and tubular fluid-electrolyte transport actions that are predictive of a hypotensive effect. The study sought to determine the improvement of hypertension and cardiac function by overexpress...

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Главные авторы: Xiao, Bin, Li, Xuguang, Yan, Jiangtao, Yu, Xuefeng, Yang, Guangtian, Xiao, Xiao, Voltz, James W., Zeldin, Darryl C., Wang, Dao Wen
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2010
Предметы:
Cardiovascular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939659/
https://ncbi.nlm.nih.gov/pubmed/20501636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.167510
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