In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR)

BACKGROUND: While increasing numbers of small interfering RNA (siRNA) therapeutics enter into clinical trials, the quantification of siRNA from clinical samples for pharmacokinetic studies remains a challenge. This challenge is even more acute for the quantification of chemically modified and formul...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Landesman, Yosef, Svrzikapa, Nenad, Cognetta, Armand, Zhang, Xuemei, Bettencourt, Brian R, Kuchimanchi, Satya, Dufault, Keri, Shaikh, Sarfraz, Gioia, Maple, Akinc, Akin, Hutabarat, Renta, Meyers, Rachel
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Methodology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939650/
https://ncbi.nlm.nih.gov/pubmed/20731861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-907X-1-16
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge