Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

BACKGROUND: Plasmodium falciparum apical membrane antigen-1 (AMA1) is a leading malaria vaccine candidate antigen that is expressed by sporozoite, liver and blood stage parasites. Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was de...

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Autors principals: Sedegah, Martha, Kim, Yohan, Peters, Bjoern, McGrath, Shannon, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna, Belmonte, Maria, Sayo, Renato, Farooq, Fouzia, Doolan, Denise L, Regis, David, Tamminga, Cindy, Chuang, Ilin, Bruder, Joseph T, King, C Richter, Ockenhouse, Christian F, Faber, Bart, Remarque, Edmond, Hollingdale, Michael R, Richie, Thomas L, Sette, Alessandro
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939619/
https://ncbi.nlm.nih.gov/pubmed/20735847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-9-241
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