Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8(+) T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1

BACKGROUND: Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8(+) T cells targeting liver stage antigens can mediat...

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Detalhes bibliográficos
Main Authors: Schwenk, Robert, Banania, Glenna, Epstein, Judy, Kim, Yohan, Peters, Bjoern, Belmonte, Maria, Ganeshan, Harini, Huang, Jun, Reyes, Sharina, Stryhn, Anette, Ockenhouse, Christian F, Buus, Soren, Richie, Thomas L, Sedegah, Martha
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819688/
https://ncbi.nlm.nih.gov/pubmed/24168370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-376
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