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Molecular Determinants for Competitive Inhibition of α4β2 Nicotinic Acetylcholine Receptors

The Erythrina alkaloids erysodine and dihydro-β-erythroidine (DHβE) are potent and selective competitive inhibitors of α4β2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants of the sensitivity of this receptor subtype to inhibition by this class of anta...

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Detalhes bibliográficos
Main Authors: Iturriaga-Vásquez, Patricio, Carbone, Annalisa, García-Beltrán, Olimpo, Livingstone, Phil D., Biggin, Philip C., Cassels, Bruce K., Wonnacott, Susan, Zapata-Torres, Gerald, Bermudez, Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939478/
https://ncbi.nlm.nih.gov/pubmed/20547737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065490
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