Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

Abnormalities in endothelium-dependent arterial relaxation develop early in atherosclerosis and may, in part, result from the effects of modified low-density lipoprotein (LDL) on agonist-mediated endothelium-derived relaxing factor (EDRF) release and EDRF degradation. alpha-Tocopherol (AT) is the ma...

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Pubblicato in:	J Clin Invest
Autori principali:	Keaney, J F, Gaziano, J M, Xu, A, Frei, B, Curran-Celentano, J, Shwaery, G T, Loscalzo, J, Vita, J A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293946/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8113416/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117039
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