Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

Abnormalities in endothelium-dependent arterial relaxation develop early in atherosclerosis and may, in part, result from the effects of modified low-density lipoprotein (LDL) on agonist-mediated endothelium-derived relaxing factor (EDRF) release and EDRF degradation. alpha-Tocopherol (AT) is the ma...

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Bibliographic Details
Main Authors: Keaney, J F, Gaziano, J M, Xu, A, Frei, B, Curran-Celentano, J, Shwaery, G T, Loscalzo, J, Vita, J A
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC293946/
https://ncbi.nlm.nih.gov/pubmed/8113416
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