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Lack of Efficacy of NMDA Receptor-NR2B Selective Antagonists in the R6/2 Model of Huntington Disease
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is a probable proximate mechanism of neurodegeneration in Huntington disease (HD). Striatal neurons express the NR2B-NMDAR subunit at high levels, and this subunit is thought to be instrumental in causing excitotoxic striatal neuron injur...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939157/ https://ncbi.nlm.nih.gov/pubmed/20659453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2010.07.015 |
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