A Proteomic Screen for Nucleolar SUMO Targets Shows SUMOylation Modulates the Function of Nop5/Nop58

Posttranslational SUMO modification is an important mechanism of regulating protein function, especially in the cell nucleus. The nucleolus is the subnuclear organelle responsible for rRNA synthesis, processing, and assembly of the large and small ribosome subunits. Here, we have used SILAC-based qu...

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Autori principali: Westman, Belinda J., Verheggen, Céline, Hutten, Saskia, Lam, Yun Wah, Bertrand, Edouard, Lamond, Angus I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938476/
https://ncbi.nlm.nih.gov/pubmed/20797632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.025
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