A Proteomic Screen for Nucleolar SUMO Targets Shows SUMOylation Modulates the Function of Nop5/Nop58

Posttranslational SUMO modification is an important mechanism of regulating protein function, especially in the cell nucleus. The nucleolus is the subnuclear organelle responsible for rRNA synthesis, processing, and assembly of the large and small ribosome subunits. Here, we have used SILAC-based qu...

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Detalhes bibliográficos
Main Authors: Westman, Belinda J., Verheggen, Céline, Hutten, Saskia, Lam, Yun Wah, Bertrand, Edouard, Lamond, Angus I.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938476/
https://ncbi.nlm.nih.gov/pubmed/20797632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.025
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