Repetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate

The risk of genotoxicity of retroviral vector-delivered gene therapy targeting hematopoietic stem cells (HSCs) has been highlighted by the development of clonal dominance and malignancies in human and animal gene therapy trials. Large-animal models have proven invaluable to test the safety of retrov...

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Detalles Bibliográficos
Main Authors: Xie, Jianjun, Larochelle, Andre, Maric, Irina, Faulhaber, Marion, Donahue, Robert E., Dunbar, Cynthia E.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2010
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938356/
https://ncbi.nlm.nih.gov/pubmed/20102258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.191
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