Repetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate

The risk of genotoxicity of retroviral vector-delivered gene therapy targeting hematopoietic stem cells (HSCs) has been highlighted by the development of clonal dominance and malignancies in human and animal gene therapy trials. Large-animal models have proven invaluable to test the safety of retrov...

Full description

Saved in:
Bibliographic Details
Main Authors: Xie, Jianjun, Larochelle, Andre, Maric, Irina, Faulhaber, Marion, Donahue, Robert E., Dunbar, Cynthia E.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2010
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938356/
https://ncbi.nlm.nih.gov/pubmed/20102258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.191
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items