PLD1-dependent PKCγ activation downstream to Src is essential for the development of pathologic retinal neovascularization

Vascular endothelial growth factor (VEGF) appears to be an important mediator of pathologic retinal angiogenesis. In understanding the mechanisms of pathologic retinal neovascularization, we found that VEGF activates PLD1 in human retinal microvascular endothelial cells, and this event is dependent...

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Главные авторы: Zhang, Qiuhua, Wang, Dong, Kundumani-Sridharan, Venkatesh, Gadiparthi, Laxmisilpa, Johnson, Dianna A., Tigyi, Gabor J., Rao, Gadiparthi N.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Vascular Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938243/
https://ncbi.nlm.nih.gov/pubmed/20421451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-271478
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