PLD1-dependent PKCγ activation downstream to Src is essential for the development of pathologic retinal neovascularization

Vascular endothelial growth factor (VEGF) appears to be an important mediator of pathologic retinal angiogenesis. In understanding the mechanisms of pathologic retinal neovascularization, we found that VEGF activates PLD1 in human retinal microvascular endothelial cells, and this event is dependent...

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Detalhes bibliográficos
Main Authors: Zhang, Qiuhua, Wang, Dong, Kundumani-Sridharan, Venkatesh, Gadiparthi, Laxmisilpa, Johnson, Dianna A., Tigyi, Gabor J., Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938243/
https://ncbi.nlm.nih.gov/pubmed/20421451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-271478
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