Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of glyoxalase 1 is linked to tumour multidrug resistan...

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Bibliografske podrobnosti
Main Authors: Thornalley, Paul J., Waris, Sahar, Fleming, Thomas, Santarius, Thomas, Larkin, Sarah J., Winklhofer-Roob, Brigitte M., Stratton, Michael R., Rabbani, Naila
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938218/
https://ncbi.nlm.nih.gov/pubmed/20435681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq306
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