Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of glyoxalase 1 is linked to tumour multidrug resistan...

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Bibliografische gegevens
Hoofdauteurs: Thornalley, Paul J., Waris, Sahar, Fleming, Thomas, Santarius, Thomas, Larkin, Sarah J., Winklhofer-Roob, Brigitte M., Stratton, Michael R., Rabbani, Naila
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2010
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938218/
https://ncbi.nlm.nih.gov/pubmed/20435681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq306
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