Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of glyoxalase 1 is linked to tumour multidrug resistan...

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Detalhes bibliográficos
Main Authors: Thornalley, Paul J., Waris, Sahar, Fleming, Thomas, Santarius, Thomas, Larkin, Sarah J., Winklhofer-Roob, Brigitte M., Stratton, Michael R., Rabbani, Naila
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938218/
https://ncbi.nlm.nih.gov/pubmed/20435681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq306
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