Targeted Deletion of the 9p21 Noncoding Coronary Artery Disease Risk Interval in Mice

Sequence polymorphisms in a 58kb interval on chromosome 9p21 confer a markedly increased risk for coronary artery disease (CAD), the leading cause of death worldwide 1,2. The variants have a substantial impact on the epidemiology of CAD and other life-threatening vascular conditions since nearly a q...

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Main Authors: Visel, Axel, Zhu, Yiwen, May, Dalit, Afzal, Veena, Gong, Elaine, Attanasio, Catia, Blow, Matthew J., Cohen, Jonathan C., Rubin, Edward M., Pennacchio, Len A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938076/
https://ncbi.nlm.nih.gov/pubmed/20173736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08801
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