Accessibility of Cholesterol in Endoplasmic Reticulum Membranes and Activation of SREBP-2 Switch Abruptly at a Common Cholesterol Threshold

Recent studies have shown that cooperative interactions in endoplasmic reticulum (ER) membranes between Scap, cholesterol, and Insig result in switch-like control over activation of SREBP-2 transcription factors. This allows cells to rapidly adjust rates of cholesterol synthesis and uptake in respon...

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Detaylı Bibliyografya
Asıl Yazarlar: Sokolov, Anna, Radhakrishnan, Arun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Membrane Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937980/
https://ncbi.nlm.nih.gov/pubmed/20573965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.148254
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