Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores

The increased risk of venous thromboembolism in cancer patients has been attributed to enhanced tissue factor (TF) procoagulant activity (PCA) on the surface of cancer cells. Recent studies have shown that TF PCA can be modulated by GRP78, an endoplasmic reticulum (ER)-resident molecular chaperone....

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Main Authors: Al-Hashimi, Ali A., Caldwell, Jennifer, Gonzalez-Gronow, Mario, Pizzo, Salvatore V., Aboumrad, Danya, Pozza, Lindsay, Al-Bayati, Hiam, Weitz, Jeffrey I., Stafford, Alan, Chan, Howard, Kapoor, Anil, Jacobsen, Donald W., Dickhout, Jeffrey G., Austin, Richard C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937918/
https://ncbi.nlm.nih.gov/pubmed/20605795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.119107
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