Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N(6)-threonylcarbamoyladenosine in tRNA

Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified adenosine, 2-methylthio-N(6)-threonylcarbamoyladenosine, at position 37 (A(37)) adjacent to the 3′-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. Using a c...

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Autori principali: Arragain, Simon, Handelman, Samuel K., Forouhar, Farhad, Wei, Fan-Yan, Tomizawa, Kazuhito, Hunt, John F., Douki, Thierry, Fontecave, Marc, Mulliez, Etienne, Atta, Mohamed
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937867/
https://ncbi.nlm.nih.gov/pubmed/20584901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106831
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