Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates

Coronaviruses encode two classes of cysteine proteases, which have narrow substrate specificities and either a chymotrypsin- or papain-like fold. These enzymes mediate the processing of the two precursor polyproteins of the viral replicase and are also thought to modulate host cell functions to faci...

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Detalhes bibliográficos
Main Authors: Wojdyla, Justyna A., Manolaridis, Ioannis, van Kasteren, Puck B., Kikkert, Marjolein, Snijder, Eric J., Gorbalenya, Alexander E., Tucker, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937765/
https://ncbi.nlm.nih.gov/pubmed/20668092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00898-10
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