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Reduced Fitness in Cell Culture of HIV-1 with Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Mutations Correlates with Relative Levels of Reverse Transcriptase Content and RNase H Activity in Virions

Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of multidrug therapy for HIV-1. Understanding the effect of NNRTI-resistant mutants on virus replication and reverse transcriptase (RT) function is valuable for the development of extended-spectrum NNRTIs. We measu...

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Main Authors: Wang, Jiong, Bambara, Robert A., Demeter, Lisa M., Dykes, Carrie
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937627/
https://ncbi.nlm.nih.gov/pubmed/20592075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00618-10
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