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Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression

Subjecting cardiomyocytes to mechanical stress or neurohumoral stimulation causes cardiac hypertrophy characterized in part by reactivation of the fetal cardiac gene program. Here we demonstrate a new common mechanism by which these stimuli are transduced to a signal activating the hypertrophic gene...

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Main Authors: Kuwahara, Koichiro, Kinoshita, Hideyuki, Kuwabara, Yoshihiro, Nakagawa, Yasuaki, Usami, Satoru, Minami, Takeya, Yamada, Yuko, Fujiwara, Masataka, Nakao, Kazuwa
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937559/
https://ncbi.nlm.nih.gov/pubmed/20606005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00154-10
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