Chargement en cours...

Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5′-Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma gondii

The orotidine-5′-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Fox, Barbara A., Bzik, David J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937452/
https://ncbi.nlm.nih.gov/pubmed/20605980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00287-10
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!