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Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5′-Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma gondii

The orotidine-5′-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of...

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Bibliografiska uppgifter
Huvudupphovsmän: Fox, Barbara A., Bzik, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937452/
https://ncbi.nlm.nih.gov/pubmed/20605980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00287-10
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