Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

Neutrophils rely on exocytosis to mobilize receptors and adhesion molecules and to release microbicidal factors. This process should be strictly regulated because uncontrolled release of toxic proteins would be injurious to the host. In vivo studies showed that the small GTPase Rab27a regulates azur...

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Autores principales: Johnson, Jennifer L., Brzezinska, Agnieszka A., Tolmachova, Tanya, Munafo, Daniela B., Ellis, Beverly A., Seabra, Miguel C, Hong, Hong, Catz, Sergio D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937183/
https://ncbi.nlm.nih.gov/pubmed/20028487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.01029.x
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