TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

OBJECTIVES: The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS: B6, B6.MyD88(−/−), B6.TLR7(−/−) and B6.TLR9(−/−)...

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Bibliografische gegevens
Hoofdauteurs: Pan, Zi-jian, Maier, Shannon, Schwarz, Karen, Azbill, Jennifer, Akira, Shizuo, Uematsu, Satoshi, Farris, A. Darise
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936817/
https://ncbi.nlm.nih.gov/pubmed/19674980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2009.108282
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