TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

OBJECTIVES: The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS: B6, B6.MyD88(−/−), B6.TLR7(−/−) and B6.TLR9(−/−)...

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Autores principales: Pan, Zi-jian, Maier, Shannon, Schwarz, Karen, Azbill, Jennifer, Akira, Shizuo, Uematsu, Satoshi, Farris, A. Darise
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936817/
https://ncbi.nlm.nih.gov/pubmed/19674980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2009.108282
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