TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

OBJECTIVES: The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS: B6, B6.MyD88(−/−), B6.TLR7(−/−) and B6.TLR9(−/−)...

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Main Authors: Pan, Zi-jian, Maier, Shannon, Schwarz, Karen, Azbill, Jennifer, Akira, Shizuo, Uematsu, Satoshi, Farris, A. Darise
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936817/
https://ncbi.nlm.nih.gov/pubmed/19674980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2009.108282
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