Suppression of Liver Regeneration and Hepatocyte Proliferation in Glypican 3 Hepatocyte-targeted Transgenic Mice

Glypican 3 (GPC3) belongs to a family of glycosylphosphatidylinositol-anchored, cell-surface heparan sulfate proteoglycans. GPC3 is over-expressed in hepatocellular carcinomas (HCC). Loss-of-function mutations of GPC3 result in the Simpson-Golabi-Behmel syndrome, an X-linked disorder characterized b...

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Autori principali: Liu, Bowen, Bell, Aaron W., Paranjpe, Shirish, Bowen, William C., Khillan, Jaspal S., Luo, Jian-Hua, Mars, Wendy M., Michalopoulos, George K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936713/
https://ncbi.nlm.nih.gov/pubmed/20812357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23794
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