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Noninvasive molecular imaging of c-Myc activation in living mice

The cytoplasmic Myc protein (c-Myc) regulates various human genes and is dysregulated in many human cancers. Phosphorylation mediates the protein activation of c-Myc and is essential for the function of this transcription factor in normal cell behavior and tumor growth. To date, however, the targeti...

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Autori principali: Fan-Minogue, Hua, Cao, Zhongwei, Paulmurugan, Ramasamy, Chan, Carmel T., Massoud, Tarik F., Felsher, Dean W., Gambhir, Sanjiv S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936612/
https://ncbi.nlm.nih.gov/pubmed/20713710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007443107
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