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High Resolution Models of Transcription Factor-DNA Affinities Improve In Vitro and In Vivo Binding Predictions

Accurately modeling the DNA sequence preferences of transcription factors (TFs), and using these models to predict in vivo genomic binding sites for TFs, are key pieces in deciphering the regulatory code. These efforts have been frustrated by the limited availability and accuracy of TF binding site...

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Detalhes bibliográficos
Main Authors: Agius, Phaedra, Arvey, Aaron, Chang, William, Noble, William Stafford, Leslie, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936517/
https://ncbi.nlm.nih.gov/pubmed/20838582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000916
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