Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: two protective CFTR-dependent thiols against oxidative injury

BACKGROUND: Cystic fibrosis is a debilitating lung disease due to mutations in the cystic fibrosis transmembrane conductance regulator protein (CFTR) and is associated with chronic infections resulting in elevated myeloperoxidase activity and generation of hypochlorous acid (HOCl). CFTR mutations le...

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Detalhes bibliográficos
Main Authors: Gould, Neal S, Gauthier, Steve, Kariya, Chirag T, Min, Elysia, Huang, Jie, Brian, Day J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936384/
https://ncbi.nlm.nih.gov/pubmed/20799947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-119
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