A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

BACKGROUND: Targeting Signal Transducer and Activator of Transcription 3 (STAT3) signaling is an attractive therapeutic approach for most types of human cancers with constitutively activated STAT3. A novel small molecular STAT3 inhibitor, FLLL32 was specifically designed from dietary agent, curcumin...

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Hlavní autoři: Lin, Li, Deangelis, Stephanie, Foust, Elizabeth, Fuchs, James, Li, Chenglong, Li, Pui-Kai, Schwartz, Eric B, Lesinski, Gregory B, Benson, Don, Lü, Jiagao, Hoyt, Dale, Lin, Jiayuh
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936338/
https://ncbi.nlm.nih.gov/pubmed/20712901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-217
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