Novel STAT3 phosphorylation inhibitors exhibit potent growth suppressive activity in pancreatic and breast cancer cells

The constitutive activation of Signal Transducer and Activator of Transcription 3 (STAT3) is frequently detected in most types of human cancer where it plays important roles in survival, drug-resistance, angiogenesis, and other functions. Targeting constitutive STAT3 signaling is thus an attractive...

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Hauptverfasser: Lin, Li, Hutzen, Brian, Zuo, Mingxin, Ball, Sarah, Deangelis, Stephanie, Foust, Elizabeth, Pandit, Bulbul, Ihnat, Michael A., Shenoy, Satyendra S., Kulp, Samuel, Li, Pui-Kai, Li, Chenglong, Fuchs, James, Lin, Jiayuh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843552/
https://ncbi.nlm.nih.gov/pubmed/20215512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2468
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