Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury

AIMS: Protein kinase C epsilon (PKCε) is critical for cardiac protection from ischaemia and reperfusion (IR) injury. PKCε substrates that mediate cytoprotection reside in the mitochondria. However, the mechanism enabling mitochondrial translocation and import of PKCε to enable phosphorylation of the...

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Detalhes bibliográficos
Main Authors: Budas, Grant R., Churchill, Eric N., Disatnik, Marie-Hélène, Sun, Lihan, Mochly-Rosen, Daria
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Original Articles: Focus on Mitochondria in Cardiac Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936125/
https://ncbi.nlm.nih.gov/pubmed/20558438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq154
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