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Being mindful of seven-transmembrane receptor ‘guests’ when assessing agonist selectivity
The time-honored approach of quantifying agonist selectivity through measurement of agonist affinity with binding and efficacy through potency ratios in model assays for prediction of effect in therapeutic systems can fall short of providing useful answers for functionally selective agonists. Agonis...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936014/ https://ncbi.nlm.nih.gov/pubmed/20590598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00764.x |
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