The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase

BACKGROUND AND PURPOSE: KMUP-1 is known to increase cGMP, enhance endothelial nitric oxide synthase (eNOS) and suppress Rho kinase (ROCK) expression in smooth muscle. Here, we investigated the mechanism of action of KMUP-1 on acute and chronic pulmonary artery hypertension (PAH) in rats. EXPERIMENTA...

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Hauptverfasser: Chung, Hui-Hsuan, Dai, Zen-Kong, Wu, Bin-Nan, Yeh, Jwu-Lai, Chai, Chee-Yin, Chu, Koung-Shing, Liu, Chung-Pin, Chen, Ing-Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2010
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936002/
https://ncbi.nlm.nih.gov/pubmed/20590592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00740.x
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