Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

A wide variety of agents activate AMPK, but in many cases the mechanisms remain unclear. We generated isogenic cell lines stably expressing AMPK complexes containing AMP-sensitive (wild-type, WT) or AMP-insensitive (R531G) γ2 variants. Mitochondrial poisons such as oligomycin and dinitrophenol only...

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Autori principali: Hawley, Simon A., Ross, Fiona A., Chevtzoff, Cyrille, Green, Kevin A., Evans, Ashleigh, Fogarty, Sarah, Towler, Mhairi C., Brown, Laura J., Ogunbayo, Oluseye A., Evans, A. Mark, Hardie, D. Grahame
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935965/
https://ncbi.nlm.nih.gov/pubmed/20519126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.04.001
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