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Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis

Under various conditions mammals have the ability to maintain serum glucose concentration within a narrow range. SIRT1 plays an important role in regulating gluconeogenesis and fat metabolism; however, the underlying mechanisms remain elusive. Here we show that SIRT1 forms a complex with FOXO3a and...

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Bibliografiset tiedot
Päätekijät:	Kim, Hyun-Seok, Xiao, Cuiying, Wang, Rui-Hong, Lahusen, Tyler, Xu, Xiaoling, Vassilopoulos, Athanassios, Vazquez-Ortiz, Guelaguetza, Jeong, Won-Il, Park, Ogyi, Ki, Sung Hwan, Gao, Bin, Deng, Chu-Xia
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	2010
Aiheet:	Article
Linkit:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2935915/ https://ncbi.nlm.nih.gov/pubmed/20816089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.06.009
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Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis

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