Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis

Under various conditions mammals have the ability to maintain serum glucose concentration within a narrow range. SIRT1 plays an important role in regulating gluconeogenesis and fat metabolism; however, the underlying mechanisms remain elusive. Here we show that SIRT1 forms a complex with FOXO3a and...

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Autors principals: Kim, Hyun-Seok, Xiao, Cuiying, Wang, Rui-Hong, Lahusen, Tyler, Xu, Xiaoling, Vassilopoulos, Athanassios, Vazquez-Ortiz, Guelaguetza, Jeong, Won-Il, Park, Ogyi, Ki, Sung Hwan, Gao, Bin, Deng, Chu-Xia
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935915/
https://ncbi.nlm.nih.gov/pubmed/20816089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.06.009
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