Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor

Microtubules are a well-validated target for anticancer therapy. Molecules that bind tubulin affect dynamic instability of microtubules causing mitotic arrest of proliferating cells, leading to cell death and tumor growth inhibition. Natural antitubulin agents such as taxanes and Vinca alkaloids hav...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Tuma, Maria Carolina, Malikzay, Asra, Ouyang, Xiaohu, Surguladze, David, Fleming, James, Mitelman, Stan, Camara, Margarita, Finnerty, Bridget, Doody, Jacqueline, Chekler, Eugene L P, Kussie, Paul, Tonra, James R
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935635/
https://ncbi.nlm.nih.gov/pubmed/20885894
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares