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Can size alone explain some of the differences in toxicity between β-amyloid oligomers and fibrils?
β-amyloid (Aβ) peptide is believed to play a key role in the mechanism of Alzheimer’s disease (AD). Aβ tends to aggregate to form amyloid fibrils. A variety of evidence indicates that Aβ aggregates are toxic in-vitro and in-vivo. An early ‘Aβ hypothesis’ postulated that AD was the consequence of neu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935630/ https://ncbi.nlm.nih.gov/pubmed/20148403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.22691 |
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