Induced Chromosomal Proximity and the Genesis of Gene Fusions in Prostate Cancer

Gene fusions have a critical role in cancer progression. Mechanisms associated with the genesis and cell type specificity of these fusions are not well understood. A prototypical gene fusion, TMPRSS2-ERG, involves the 5’ untranslated region of the androgen-regulated gene TMPRSS2 with the ERG gene, a...

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Main Authors: Mani, Ram-Shankar, Tomlins, Scott A., Callahan, Kaitlin, Ghosh, Aparna, Nyati, Mukesh K., Varambally, Sooryanarayana, Palanisamy, Nallasivam, Chinnaiyan, Arul M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935583/
https://ncbi.nlm.nih.gov/pubmed/19933109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178124
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