Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus

Crystal structures of a binary Mg(2+)-form Dpo4–DNA complex with 1,N (2)-etheno-dG in the template strand as well as of ternary Mg(2+)-form Dpo4–DNA–dCTP/dGTP complexes with 8-oxoG in the template strand have been determined. Comparison of their conformations and active-site geometries with those of...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Irimia, Adriana, Loukachevitch, Lioudmila V., Eoff, Robert L., Guengerich, F. Peter, Egli, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2010
Ämnen:
Structural Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935216/
https://ncbi.nlm.nih.gov/pubmed/20823515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110029374
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