Secondary Integrase Resistance Mutations Found in HIV-1 Minority Quasispecies in Integrase Therapy-Naive Patients Have Little or No Effect on Susceptibility to Integrase Inhibitors

The goal of this study was to explore the presence of integrase strand transfer inhibitor (InSTI) resistance mutations in HIV-1 quasispecies present in InSTI-naïve patients and to evaluate their in vitro effects on phenotypic susceptibility to InSTIs and their replication capacities. The RT-RNase H-...

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Main Authors: Ceccherini-Silberstein, Francesca, Van Baelen, Kurt, Armenia, Daniele, Trignetti, Maria, Rondelez, Evelien, Fabeni, Lavinia, Scopelliti, Fernanda, Pollicita, Michela, Van Wesenbeeck, Liesbeth, Van Eygen, Veerle, Dori, Luca, Sarmati, Loredana, Aquaro, Stefano, Palamara, Guido, Andreoni, Massimo, Stuyver, Lieven J., Perno, Carlo Federico
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935022/
https://ncbi.nlm.nih.gov/pubmed/20479206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01720-09
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