p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101

Functional inactivation of the tumor susceptibility gene tsg101 in NIH 3T3 fibroblasts results in cellular transformation and the ability to form metastatic tumors in nude mice. The N-terminal region of tsg101 protein is structurally similar to the catalytic domain of ubiquitin-conjugating enzymes,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ruland, Jürgen, Sirard, Christian, Elia, Andrew, MacPherson, David, Wakeham, Andrew, Li, Limin, Luis de la Pompa, José, Cohen, Stanley N., Mak, Tak W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29347/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11172041/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.4.1859
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