The Lipid-binding Domain of Wild Type and Mutant α-Synuclein: COMPACTNESS AND INTERCONVERSION BETWEEN THE BROKEN AND EXTENDED HELIX FORMS

α-Synuclein (αS) is linked to Parkinson disease through its deposition in an amyloid fibril form within Lewy Body deposits, and by the existence of three αS point mutations that lead to early onset autosomal dominant Parkinsonism. The normal function of αS is thought to be linked to the ability of t...

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Bibliographic Details
Main Authors: Georgieva, Elka R., Ramlall, Trudy F., Borbat, Peter P., Freed, Jack H., Eliezer, David
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934691/
https://ncbi.nlm.nih.gov/pubmed/20592036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.157214
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