Knockdown of Zebrafish Lumican Gene (zlum) Causes Scleral Thinning and Increased Size of Scleral Coats

The lumican gene (lum), which encodes one of the major keratan sulfate proteoglycans (KSPGs) in the vertebrate cornea and sclera, has been linked to axial myopia in humans. In this study, we chose zebrafish (Danio rerio) as an animal model to elucidate the role of lumican in the development of axial...

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Main Authors: Yeh, Lung-Kun, Liu, Chia-Yang, Kao, Winston W.-Y., Huang, Chang-Jen, Hu, Fung-Rong, Chien, Chung-Liang, Wang, I-Jong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934679/
https://ncbi.nlm.nih.gov/pubmed/20551313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043679
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