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Essential Role of the CBD1-CBD2 Linker in Slow Dissociation of Ca(2+) from the Regulatory Two-domain Tandem of NCX1
In NCX proteins CBD1 and CBD2 domains are connected through a short linker (3 or 4 amino acids) forming a regulatory tandem (CBD12). Only three of the six CBD12 Ca(2+)-binding sites contribute to NCX regulation. Two of them are located on CBD1 (K(d) = ∼0.2 μm), and one is on CBD2 (K(d) = ∼5 μm). Her...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934676/ https://ncbi.nlm.nih.gov/pubmed/20587421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127001 |
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