GRIM-19 and p16(INK4a) Synergistically Regulate Cell Cycle Progression and E2F1-responsive Gene Expression

GRIM-19 (Gene associated with Retinoid-IFN-induced Mortality-19) was originally isolated as a growth suppressor in a genome-wide knockdown screen with antisense libraries. Like classical tumor suppressors, mutations, and/or loss of GRIM-19 expression occur in primary human tumors; and it is inactiva...

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Autors principals: Sun, Peng, Nallar, Shreeram C., Raha, Abhijit, Kalakonda, Sudhakar, Velalar, Chidambaram N., Reddy, Sekhar P., Kalvakolanu, Dhananjaya V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934621/
https://ncbi.nlm.nih.gov/pubmed/20522552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105767
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