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Direct and Indirect Roles of the LTβR Pathway in Central Tolerance Induction
Medullary thymic epithelial cells (mTECs) play a critical role in thymic negative selection of autoreactive thymocytes, especially for thymocytes specific for peripheral tissue-restricted self-antigens (TRA). Deficiency in LTβR is associated with peripheral tissue inflammation but whether it is caus...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933296/ https://ncbi.nlm.nih.gov/pubmed/20675191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2010.06.005 |
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