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A split active site couples cap recognition by Dcp2 to activation
Decapping by Dcp2 is an essential step in 5′-3′ mRNA decay. In yeast, decapping requires an open-to-closed transition in Dcp2, though the link between closure and catalysis remains elusive. Here we show using NMR that cap binds conserved residues on both the catalytic and regulatory domains of Dcp2....
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933276/ https://ncbi.nlm.nih.gov/pubmed/20711189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1879 |
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